(4,5-dimethylcyclohex-4-ene-1,2-diyl)bis(phenylmethanone) → HCID 10494397, compound

HRID 1952833Notes

Reaction equation

HRID 1952833 reaction equation
[CH3:1][C:2]1[CH2:7][CH:6]([C:8](=O)[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:5]([C:16](=O)[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:4][C:3]=1[CH3:24].C([O-])=O.[NH4+:28]>C(O)C>[C:9]1([C:8]2[NH:28][C:16]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[C:5]3[C:6]=2[CH2:7][C:2]([CH3:1])=[C:3]([CH3:24])[CH2:4]3)[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Participants

4

Reactant 2

HCID 248879(4,5-dimethylcyclohex-4-ene-1,2-diyl)bis(phenylmethanone)HCID 2723923Ammonium formate

Product 1

HCID 10494397HCID 10494397, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution containing 4.46 g of 1,2-dimethyl-4,5-dibenzoylcyclohexene (Preparation 1) and 8.81 g of ammonium formate in 70 ml of anhydrous ethanol is heated at reflux for 24 hours. A precipitate is obtained which is filtered off and then dissolved in dichloromethane. The organic phase is washed with water, dried over calcium sulphate and concentrated to allow the isolation of 4 g of the expected product.

Workup

  1. temperatureis heated
  2. temperatureat reflux for 24 hours
  3. customA precipitate is obtained which
  4. filtrationis filtered off
  5. dissolutiondissolved in dichloromethane
  6. washThe organic phase is washed with water
  7. dry with materialdried over calcium sulphate
  8. concentrationconcentrated

Sources & evidence

ORD record
ord-ce56dddde5414fcbae0036362513ac63
Source dataset
uspto-grants-2000_09
Patent number
US06114360

Reaction notes

Loading…