Trifluoroacetic acid → HCID 23301372, compound

HRID 1952837Notes

Reaction equation

HRID 1952837 reaction equation
FC(F)(F)C(O)=O.[C:8]1([C:14]2[N:15]([CH2:29][C:30]([O:32]C(C)(C)C)=[O:31])[C:16]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)=[C:17]3[C:22]=2[CH2:21][CH:20]=[CH:19][CH2:18]3)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>ClCCl>[C:23]1([C:16]2[N:15]([CH2:29][C:30]([OH:32])=[O:31])[C:14]([C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=3)=[C:22]3[C:17]=2[CH2:18][CH:19]=[CH:20][CH2:21]3)[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 23301391HCID 23301391, compound

Product 1

HCID 23301372HCID 23301372, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

5 ml of trifluoroacetic acid are added at 0° C. to a solution of 5 g of the compound of Step A in 50 ml of anhydrous dichloromethane. After reaction for 12 hours at ambient temperature, the reaction mixture is concentrated in vacuo and the residue obtained is rinsed with ether to allow isolation of the expected product.

Workup

  1. customAfter reaction for 12 hours at ambient temperature
  2. concentrationthe reaction mixture is concentrated in vacuo
  3. customthe residue obtained
  4. washis rinsed with ether

Sources & evidence

ORD record
ord-39aa1747e8f64408b1932be02e239204
Source dataset
uspto-grants-2000_09
Patent number
US06114360

Reaction notes

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