反应详情

120 g (743 mmol) of 5-chloromethylisoxazole-3-carboxylic acid were refluxed together with 500 ml of thionyl chloride and 2 drops of pyridine for 10 h, then concentrated under reduced pressure and subsequently distilled under 20 torr. The product distilled at 125-133° C. to result in 78 g (58% of theory).

1. concentrationconcentrated under reduced pressure
2. distillationsubsequently distilled under 20 torr
3. distillationThe product distilled at 125-133° C.
4. customto result in 78 g (58% of theory)