HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 5-(Chloromethyl)-1,2-oxazole-3-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 5-(Chloromethyl)-1,2-oxazole-3-carboxylic acid | HCID 21866449 | — |
| Catalyst | Pyridine | HCID 1049 | — |
| Product | 5-(Chloromethyl)-1,2-oxazole-3-carbonyl chloride | HCID 13001899 | — |
Reaction Steps
120 g (743 mmol) of 5-chloromethylisoxazole-3-carboxylic acid were refluxed together with 500 ml of thionyl chloride and 2 drops of pyridine for 10 h, then concentrated under reduced pressure and subsequently distilled under 20 torr. The product distilled at 125-133° C. to result in 78 g (58% of theory).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06114358 |
| Source dataset | uspto-grants-2000_09 |
| ORD ID | ord-4eec5157effa424dbf14b7ea8105e34c |
| Source note | uspto-grants-2000_09 |