HuagongsheHuagongshe Chemistry Print Report · For research reference only
O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate → (R)N-[[3-(aminocarbonylaminomethyl)phenyl]methyl]-N5-[amino(nitroimino]methyl]-N2-(diphenylacetyl)-ornithinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 3-(Amino-carbonylaminomethyl)benzenemethanamine | HCID 15480559 | — |
| Reactant | (R)-N5-[amino(nitroimino)methyl]-N2-(diphenylacetyl)-ornithine | HCID 136381100 | — |
| Product | (R)N-[[3-(aminocarbonylaminomethyl)phenyl]methyl]-N5-[amino(nitroimino]methyl]-N2-(diphenylacetyl)-ornithinamide | HCID 136333684 | 50% |
Reaction Steps
Prepared analogously to Example 4b) from (R)-N5 -[amino(nitroimino]methyl]-N2 -(diphenylacetyl)-ornithine, 3-(amino-carbonylaminomethyl)benzenemethanamine and TBTU in a yield of 50% of theory. Colourless amorphous substance.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06114390 |
| Source dataset | uspto-grants-2000_09 |
| ORD ID | ord-58e7e5223fbb4a78a445579423555b38 |
| Source note | uspto-grants-2000_09 |