HRID1952992

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID176

Acetic Acid

C2H4O2

结构：NC(=O)NCc1cccc(CNC(=O)[C@@H](CCCNC(N)=N[N+](=O)[O-])NC(=O)C(c2ccccc2)c2ccccc2)c1

HCID136333684

未命名化合物

PRODUCTS

生成物

结构：CC(=O)[O-].N=C(N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1cccc(CNC(N)=O)c1

HCID178476713

未命名化合物

收率 42%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

PROCEDURE

实验过程

Prepared analogously to Example 4c) from (R)N-[[3-(aminocarbonylaminomethyl)phenyl]methyl]-N5 -[amino(nitroimino]methyl]-N2 -(diphenylacetyl)-ornithinamide by catalytic hydrogenation in the presence of palladium black and 80% acetic acid in a yield of 42% of theory.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d9a78f6063ac4e1b9954f714954424a2
来源数据集: uspto-grants-2000_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06114390
来源说明: uspto-grants-2000_09

反应 SMILES

[NH2:1][C:2]([NH:4][CH2:5][C:6]1[CH:7]=[C:8]([CH2:12][NH:13][C:14](=[O:42])[C@@H:15]([CH2:32][CH2:33][CH2:34][NH:35][C:36]([NH2:41])=[N:37][N+]([O-])=O)[NH:16][C:17](=[O:31])[CH:18]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:9]=[CH:10][CH:11]=1)=[O:3].[C:43]([OH:46])(=[O:45])[CH3:44]>[Pd]>[NH2:1][C:2]([NH:4][CH2:5][C:6]1[CH:7]=[C:8]([CH2:12][NH:13][C:14](=[O:42])[C@@H:15]([CH2:32][CH2:33][CH2:34][NH:35][C:36](=[NH:37])[NH2:41])[NH:16][C:17](=[O:31])[CH:18]([C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:9]=[CH:10][CH:11]=1)=[O:3].[C:43]([O-:46])(=[O:45])[CH3:44]