HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → (R)-N-[[3-(Aminocarbonylaminomethyl)phenyl]methyl]-N2-(diphenylacetyl)-argininamide acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | (R)N-[[3-(aminocarbonylaminomethyl)phenyl]methyl]-N5-[amino(nitroimino]methyl]-N2-(diphenylacetyl)-ornithinamide | HCID 136333684 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | (R)-N-[[3-(Aminocarbonylaminomethyl)phenyl]methyl]-N2-(diphenylacetyl)-argininamide acetate | HCID 178476713 | 42% |
Reaction Steps
Prepared analogously to Example 4c) from (R)N-[[3-(aminocarbonylaminomethyl)phenyl]methyl]-N5 -[amino(nitroimino]methyl]-N2 -(diphenylacetyl)-ornithinamide by catalytic hydrogenation in the presence of palladium black and 80% acetic acid in a yield of 42% of theory.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06114390 |
| Source dataset | uspto-grants-2000_09 |
| ORD ID | ord-d9a78f6063ac4e1b9954f714954424a2 |
| Source note | uspto-grants-2000_09 |