Benzeneacetic acid, 4-methoxy-alpha-(4-methoxyphenyl)- → HCID 137182955, compound

HRID 1953007Notes

Reaction equation

HRID 1953007 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([C:13]2[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=2)[C:10]([OH:12])=O)=[CH:5][CH:4]=1.Cl.[NH2:22][C:23]([NH:25][CH2:26][C:27]1[CH:32]=[CH:31][C:30]([CH2:33][NH:34][C:35](=[O:48])[C@@H:36]([CH2:38][CH2:39][CH2:40][NH:41][C:42]([NH2:47])=[N:43][N+:44]([O-:46])=[O:45])[NH2:37])=[CH:29][CH:28]=1)=[O:24].CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F>C(#N)C>[NH2:22][C:23]([NH:25][CH2:26][C:27]1[CH:28]=[CH:29][C:30]([CH2:33][NH:34][C:35](=[O:48])[C@@H:36]([CH2:38][CH2:39][CH2:40][NH:41][C:42]([NH2:47])=[N:43][N+:44]([O-:46])=[O:45])[NH:37][C:10](=[O:12])[CH:9]([C:6]2[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=2)[C:13]2[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=2)=[CH:31][CH:32]=1)=[O:24]

Participants

5

Reactant 3

HCID 94979Benzeneacetic acid, 4-methoxy-alpha-(4-methoxyphenyl)-HCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 136333697HCID 136333697, compound

Product 1

HCID 137182955HCID 137182955, compoundYield 48%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Prepared analogously to Example 14c) from bis-(4-methoxyphenyl)-acetic acid, (R)-N-[[4-(aminocarbonylaminomethyl)phenyl]methyl]-N5 -[amino(nitroimino)methyl]-ornithinamidehydrochloride and TBTU in a yield of 48% of theory. Colourless crystals, Mp. 149-151° C. (Acetonitrile).

Sources & evidence

ORD record
ord-1499d3c529a34e50bb218839fab51e19
Source dataset
uspto-grants-2000_09
Patent number
US06114390

Reaction notes

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