Ammonia → HCID 23301829, compound

HRID 1953013Notes

Reaction equation

HRID 1953013 reaction equation
[NH3:1].Cl.[C:3]1([CH2:9][N:10]2[CH2:18][C:17]3[C:12](=[CH:13][CH:14]=[C:15]([C:19](Cl)=[O:20])[CH:16]=3)[CH2:11]2)[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>O1CCCC1>[C:3]1([CH2:9][N:10]2[CH2:18][C:17]3[C:12](=[CH:13][CH:14]=[C:15]([C:19]([NH2:1])=[O:20])[CH:16]=3)[CH2:11]2)[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 88078681HCID 88078681, compound

Product 1

HCID 23301829HCID 23301829, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a mixture of 200 ml of conc. aqueous ammonia and 50 ml of tetrahydrofuran were added, in batches, 20.0 g (64.9 mMol) of 2,3-dihydro-2-(phenylmethyl)-1H-isoindole-5-carboxylic acid chloride-hydrochloride and the mixture was stirred overnight at ambient temperature. The precipitate formed was suction filtered, washed thoroughly with water and dried at 50° C. in a circulating air dryer. The desired compound was obtained in a quantitative yield in the form of colourless crystals.

Workup

  1. customThe precipitate formed
  2. filtrationfiltered
  3. washwashed thoroughly with water
  4. customdried at 50° C. in a circulating air dryer

Sources & evidence

ORD record
ord-a675a4b8cae7412581d3fb278e0ac992
Source dataset
uspto-grants-2000_09
Patent number
US06114390

Reaction notes

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