Trifluoroacetic acid → HCID 86755805, compound

HRID 1953029Notes

Reaction equation

[NH2:1][C:2]([CH2:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][NH:12][C:13](=[O:37])[C@@H:14]([CH2:23][CH2:24][CH2:25][NH:26][C:27]([O:29][CH2:30][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)=[O:28])[NH:15]C(OCC(C)C)=O)=[CH:7][CH:6]=1)=[O:3].[F:38][C:39]([F:44])([F:43])[C:40]([OH:42])=[O:41]>>[NH2:1][C:2]([CH2:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][NH:12][C:13](=[O:37])[C@@H:14]([CH2:23][CH2:24][CH2:25][NH:26][C:27]([O:29][CH2:30][C:31]2[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=2)=[O:28])[NH2:15])=[CH:7][CH:6]=1)=[O:3].[F:38][C:39]([F:44])([F:43])[C:40]([O-:42])=[O:41]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 67615154HCID 67615154, compound

Product 1

HCID 86755805HCID 86755805, compound

Procedure

Prepared analogously to Example if) from (R)-N-[[4-(aminocarbonylmethyl)phenyl]methyl]-N2 -[(2,2-dimethylethoxy)carbonyl]-N5 -(phenylmethoxycarbonyl)-ornithinamide and trifluoroacetic acid in a quantitative yield. Colourless, amorphous substance which was used in the following step without purification.

Workup

customColourless, amorphous substance which was used in the following step without purification

Sources & evidence

ORD record: ord-93c25166254b4eb38a2c5db44c85ac2c
Source dataset: uspto-grants-2000_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06114390

Reaction notes

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