Pyridine → N-(4-Bromo-l-methyl-5-pyrazolyl)-S,S-dimethylsulfilimine

HRID 1953200Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1953200
[CH3:1][S:2][CH3:3].ClCl.[NH2:6][C:7]1[N:11]([CH3:12])[N:10]=[CH:9][C:8]=1[Br:13].N1C=CC=CC=1>ClCCl>[Br:13][C:8]1[CH:9]=[N:10][N:11]([CH3:12])[C:7]=1[N:6]=[S:2]([CH3:3])[CH3:1]

Komponenten

6

Edukt 4

HCID 1049PyridineHCID 1068Dimethyl SulfideHCID 24526ChlorineHCID 6003514-Bromo-1-methyl-1H-pyrazol-5-amine

Produkt 1

HCID 23303942N-(4-Bromo-l-methyl-5-pyrazolyl)-S,S-dimethylsulfilimine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of 0.60 mL (8.2 mmol) of dimethyl sulfide in 30 mL of dichloromethane was cooled to -20° C. and 0.50 g (7.0 mmol) of chlorine was added through a sparge tube with cooling and stirring. Subsequently, 1.0 g (5.7 mmol) of 5-amino-4-bromo-1-methylpyrazole and then 1.0 g (12.7 mmol) of pyridine were added with cooling and stirring. A 2 mL aliquot of this mixture was removed and the light yellow solids present were collected by filtration and washed with deuteroacetonitrile.

Aufarbeitung

  1. temperaturewith cooling
  2. temperaturewith cooling
  3. stirringstirring
  4. customA 2 mL aliquot of this mixture was removed
  5. filtrationthe light yellow solids present were collected by filtration
  6. washwashed with deuteroacetonitrile

Quellen und Nachweise

ORD-Eintrag
ord-094fdb8f9ce14445bae27c56b49e48d2
Quelldatensatz
uspto-grants-2000_09
Patentnummer
US06114580

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