Hydrochloric Acid → 2,3,4,5-Tetrafluorobenzoyl chloride

HRID 1953237Notes

Reaction equation

HRID 1953237 reaction equation
[F:1][C:2]1[C:7]([F:8])=[C:6]([F:9])[C:5]([F:10])=[CH:4][C:3]=1[C:11]([Cl:14])(Cl)Cl.Cl.[OH2:16]>>[F:1][C:2]1[C:7]([F:8])=[C:6]([F:9])[C:5]([F:10])=[CH:4][C:3]=1[C:11]([Cl:14])=[O:16]

Participants

4

Reactant 3

HCID 313Hydrochloric Acid2×HCID 962Water2×HCID 153460071,2,3,4-Tetrafluoro-5-(trichloromethyl)benzene

Product 1

HCID 27336892,3,4,5-Tetrafluorobenzoyl chlorideYield 89.3%

Procedure

802 g of 2,3,4,5-tetrafluoro-benzotrichloride are initially introduced into a stirred apparatus, and 8 g of FeCl3 are added. Water is slowly metered in under the surface of the starting material at 120° C. (54 g of water in total). Vigorous evolution of hydrogen chloride immediately starts. The hydrogen chloride is passed to a destruction tower via the condenser. The mixture is stirred until the evolution of gas has ended. The product is then distilled. 569 g of 2,3,4,5-tetrafluoro-benzoyl chloride are obtained (89.4% of theory), boiling point: 80-82° C./18 mbar.

Workup

  1. additionare added
  2. customis slowly metered in under the surface of the starting material at 120° C.
  3. distillationThe product is then distilled

Sources & evidence

ORD record
ord-a0bcc9bdacd74405852792520e0e6783
Source dataset
uspto-grants-2000_09
Patent number
US06114590

Reaction notes

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