Benzyl chloroformate → HCID 53906025, compound

HRID 1953254Notes

Reaction equation

HRID 1953254 reaction equation
Cl.[CH2:2]([O:4][C:5]([CH2:7][N:8]([S:29]([C:32]1[CH:33]=[CH:34][CH:35]=[C:36]2[C:41]=1[N:40]=[CH:39][CH:38]=[CH:37]2)(=[O:31])=[O:30])[C:9]1[CH:28]=[CH:27][C:12]2[N:13]([CH3:26])[C:14]([CH2:16][C:17]3[CH:25]=[CH:24][C:20]([C:21]([NH2:23])=[NH:22])=[CH:19][CH:18]=3)=[N:15][C:11]=2[CH:10]=1)=[O:6])[CH3:3].Cl[C:43]([O:45][CH2:46][C:47]1[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=1)=[O:44]>CC(C)=O.O>[CH2:2]([O:4][C:5]([CH2:7][N:8]([S:29]([C:32]1[CH:33]=[CH:34][CH:35]=[C:36]2[C:41]=1[N:40]=[CH:39][CH:38]=[CH:37]2)(=[O:30])=[O:31])[C:9]1[CH:28]=[CH:27][C:12]2[N:13]([CH3:26])[C:14]([CH2:16][C:17]3[CH:18]=[CH:19][C:20]([C:21]([NH2:23])=[N:22][C:43]([O:45][CH2:46][C:47]4[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=4)=[O:44])=[CH:24][CH:25]=3)=[N:15][C:11]=2[CH:10]=1)=[O:6])[CH3:3]

Participants

4

Reactant 2

HCID 10387Benzyl chloroformateHCID 23302367HCID 23302367, compound

Product 1

HCID 53906025HCID 53906025, compound

Reagents, catalysts & solvents 1

HCID 18366337Propan-2-one--water (1/1)Solvent

Procedure

Prepared analogously to Example 97 from 4-[(5-(N-ethyloxycarbonylmethyl-quinolin-8-yl-sulphonylamino)-1-methyl-1H-benzimidazol-2-yl)-methyl]-benzamidine-hydrochloride and benzyl chloroformate in acetone/water.

Sources & evidence

ORD record
ord-59040c77aadc438aba95f59e840bc552
Source dataset
uspto-grants-2000_09
Patent number
US06114532

Reaction notes

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