1-Bromopentane → HCID 54238531, compound

HRID 1953272Notes

Reaction equation

HRID 1953272 reaction equation
C(O[P:4]([C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=1)(=[O:8])[O:5][CH2:6][CH3:7])C.[CH2:16](Br)[CH2:17][CH2:18][CH2:19][CH3:20]>>[CH2:6]([O:5][P:4]([C:9]1[CH:10]=[CH:11][C:12]([Cl:15])=[CH:13][CH:14]=1)([CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])=[O:8])[CH3:7]

Participants

3

Reactant 2

HCID 80571-BromopentaneHCID 200625Phosphonic acid, (p-chlorophenyl)-, diethyl ester

Product 1

HCID 54238531HCID 54238531, compound

Procedure

3.5 g (15 mmol) of diethyl(4-chlorophenyl)-phosphonate and 3 ml (24.7 mmol) of n-pentylbromide are heated to 150° C. for 90 minutes with stirring. The cooled clear solution is chromatographed on silica gel and eluted with cyclohexane/ethyl acetate (7:3 to 1:1).

Workup

  1. customThe cooled clear solution is chromatographed on silica gel
  2. washeluted with cyclohexane/ethyl acetate (7:3 to 1:1)

Sources & evidence

ORD record
ord-c3c4d82bcb9b4d94b1ebe9cead0112e1
Source dataset
uspto-grants-2000_09
Patent number
US06114532

Reaction notes

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