4-Cyanophenylacetic acid → HCID 23302673, compound

HRID 1953279Notes

Reaction equation

HRID 1953279 reaction equation
[NH2:1][C:2]1[CH:9]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:7]=[CH:6][C:3]=1[NH:4][CH3:5].[C:16]([C:18]1[CH:23]=[CH:22][C:21]([CH2:24][C:25](O)=O)=[CH:20][CH:19]=1)#[N:17]>O1CCCC1.C(O)(=O)C>[C:10]1([C:8]2[CH:7]=[CH:6][C:3]3[N:4]([CH3:5])[C:25]([CH2:24][C:21]4[CH:22]=[CH:23][C:18]([C:16]#[N:17])=[CH:19][CH:20]=4)=[N:1][C:2]=3[CH:9]=2)[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

Participants

5

Reactant 2

HCID 795874-Cyanophenylacetic acidHCID 21250160HCID 21250160, compound

Product 1

HCID 23302673HCID 23302673, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 8028TetrahydrofuranSolvent

Procedure

Prepared analogously to Example 24f from 2-amino-4-phenyl-N-methyl-aniline, 4-cyanophenylacetic acid and N,N'-carbonyldiimidazole in tetrahydrofuran and glacial acetic acid.

Sources & evidence

ORD record
ord-9a4683ab5d5444919dac6db4dfbe54db
Source dataset
uspto-grants-2000_09
Patent number
US06114532

Reaction notes

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