反应详情

Hydrogen chloride gas is introduced into a suspension of 10 g (52.5 mmol) of 2-benzimidazole-propionic acid refluxing in 250 ml absolute ethanol over 1 hour. Then the mixture is concentrated by evaporation, the residue is dissolved in water and made alkaline with concentrated ammonia. Then it is extracted with ethyl acetate, the combined organic extracts are washed with water, dried and concentrated by evaporation.

1. concentrationThen the mixture is concentrated by evaporation
2. dissolutionthe residue is dissolved in water
3. extractionThen it is extracted with ethyl acetate
4. washthe combined organic extracts are washed with water
5. customdried
6. concentrationconcentrated by evaporation