4-Cyanophenylacetic acid → HCID 53989458, compound

HRID 1953298Notes

Reaction equation

HRID 1953298 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:22]=[CH:23][C:24]=1[NH:25][CH3:26])[CH2:5][N:6]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[N:8]=[C:7]1[CH2:15][CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18].[C:27]([C:29]1[CH:34]=[CH:33][C:32]([CH2:35][C:36](O)=O)=[CH:31][CH:30]=1)#[N:28]>O1CCCC1.C(O)(=O)C>[CH2:20]([O:19][C:17]([CH2:16][CH2:15][C:7]1[N:6]([CH2:5][C:4]2[CH:22]=[CH:23][C:24]3[N:25]([CH3:26])[C:36]([CH2:35][C:32]4[CH:31]=[CH:30][C:29]([C:27]#[N:28])=[CH:34][CH:33]=4)=[N:1][C:2]=3[CH:3]=2)[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[N:8]=1)=[O:18])[CH3:21]

Participants

5

Reactant 2

HCID 795874-Cyanophenylacetic acidHCID 23302732HCID 23302732, compound

Product 1

HCID 53989458HCID 53989458, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 8028TetrahydrofuranSolvent

Procedure

Prepared analogously to Example 24f from ethyl 3-[1-(3-amino-4-methylamino-benzyl)-1H-benzimidazol-2-yl]-propionate, 4-cyanophenylacetic acid and N,N'-carbonyldiimidazole in tetrahydrofuran, glacial acetic acid.

Sources & evidence

ORD record
ord-43df43bbe19c45af8f50a4092d02353c
Source dataset
uspto-grants-2000_09
Patent number
US06114532

Reaction notes

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