HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Bromide → (4-(Bromomethyl)phenoxy)(tert-butyl)dimethylsilane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Bromide | HCID 82050 | — |
| Reactant | 4-{(t-Butyldimethylsilyl)oxy}benzyl trifluoroacetate | HCID 9997005 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (4-(Bromomethyl)phenoxy)(tert-butyl)dimethylsilane | HCID 10380115 | 88% |
Reaction Steps
The benzyl trifluoroacetate 8 (17.9 g) was dissolved in dry THF, and dry lithium bromide (5.06 g) was added with stirring. The mixture was refluxed overnight, cooled, diluted with acetonitrile, and extracted three times with hexane. The hexane layers were combined, dried, filtered, and concentrated, thereby leaving the product 10 as a white oil in 88% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06117845 |
| Source dataset | uspto-grants-2000_09 |
| ORD ID | ord-caea78892fa840b9b949dda17bcf4585 |
| Source note | uspto-grants-2000_09 |