反应详情

A mixture of 3-vinylaniline (8 g), 2-chloro-3-nitropyridine (10.7 g) and potassium carbonate (18.6 g) in dioxane (80 ml) was stirred under reflux for 5 days. The reaction was extracted with chloroform, washed with water, dried over magnesium sulfate and evaporated. After evaporation of the solvent, crude residue was crystallized from methanol to give 2-(3-vinylphenylamino)-3-nitropyridine as an orange crystals (12.9 g).

1. temperatureunder reflux for 5 days
2. extractionThe reaction was extracted with chloroform
3. washwashed with water
4. dry with materialdried over magnesium sulfate
5. customevaporated
6. customAfter evaporation of the solvent, crude residue
7. customwas crystallized from methanol