反应详情

A mixture of 2-[3-[(E)-2-(2-acetamido-3-pyridyl)vinyl]phenylamino]-3-aminopyridine (1.86 g), iron powder (1.39 g) and ammonium chloride (0.26 g), ethanol (20 ml) and water (6 ml) was stirred under reflux for an hour. The reaction was filtered, concentrated and extracted with chloroform. The extracts were washed with saturated sodium bicarbonate solution, dried and evaporated to afford 2-[3-[(E)-2-(6-acetamido-3-pyridyl)vinyl]phenylamino]-3-aminopyridine as dark purple crystals (1.59 g).

1. temperatureunder reflux for an hour
2. filtrationThe reaction was filtered
3. concentrationconcentrated
4. extractionextracted with chloroform
5. washThe extracts were washed with saturated sodium bicarbonate solution
6. customdried
7. customevaporated