HCID 15372233, compound → HCID 23298081, compound

HRID 1953416Notes

Reaction equation

HRID 1953416 reaction equation
[C:1]([NH:4][C:5]1[N:10]=[CH:9][C:8](/[CH:11]=[CH:12]/[C:13]2[CH:14]=[C:15]([NH:19][C:20]3[C:25]([NH2:26])=[CH:24][CH:23]=[CH:22][N:21]=3)[CH:16]=[CH:17][CH:18]=2)=[CH:7][CH:6]=1)(=[O:3])[CH3:2].[N:27]1[CH:32]=[CH:31][CH:30]=[C:29]([CH2:33][C:34](=O)[C:35](O)=[O:36])[CH:28]=1>C(O)C>[N:27]1[CH:32]=[CH:31][CH:30]=[C:29]([CH2:33][C:34]2[C:35](=[O:36])[N:19]([C:15]3[CH:16]=[CH:17][CH:18]=[C:13](/[CH:12]=[CH:11]/[C:8]4[CH:9]=[N:10][C:5]([NH:4][C:1](=[O:3])[CH3:2])=[CH:6][CH:7]=4)[CH:14]=3)[C:20]3[N:21]=[CH:22][CH:23]=[CH:24][C:25]=3[N:26]=2)[CH:28]=1

Participants

4

Reactant 2

HCID 15372233HCID 15372233, compoundHCID 23298086HCID 23298086, compound

Product 1

HCID 23298081HCID 23298081, compoundYield 85.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A suspension of 2-[3-[(E)-2-(6-acetamido-3-pyridyl)vinyl]phenylamino]-3-aminopyridine (1.5 g) and 3-pyridylpyruvic acid (0.79 g) in ethanol (30 ml) was stirred under reflux for 8 hours. The cold reaction mixture was filtered and washed with ethanol to give 2-(3-pyridylmethyl)-3-oxo-4-[3-[(E)-2-(6-acetamido-3-pyridyl)vinyl]phenyl]-3,4-dihydropyrido[2,3-b]pyrazine as colorless crystals (1.76 g).

Workup

  1. temperatureunder reflux for 8 hours
  2. customThe cold reaction mixture
  3. filtrationwas filtered
  4. washwashed with ethanol

Sources & evidence

ORD record
ord-8fdde0154cca4d099ca8d48b480a8d8e
Source dataset
uspto-grants-2000_09
Patent number
US06117875

Reaction notes

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