4-Morpholinecarbonyl chloride → 1-(Morpholine-4-carboxamido)cyclohexanecarboxylic acid

HRID 1953428Notes

Reaction equation

HRID 1953428 reaction equation
Cl.[NH2:2][C:3]1([C:9]([O:11]CC)=[O:10])[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1.[N:14]1([C:20](Cl)=[O:21])[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1>>[N:14]1([C:20]([NH:2][C:3]2([C:9]([OH:11])=[O:10])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]2)=[O:21])[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1

Participants

3

Reactant 2

HCID 848104-Morpholinecarbonyl chlorideHCID 11241228Ethyl 1-aminocyclohexane-1-carboxylate hydrochloride

Product 1

HCID 115071371-(Morpholine-4-carboxamido)cyclohexanecarboxylic acidYield 33.4%

Procedure

The same reaction procedure as used in Reference Example 4 was repeated by using 4.36 g (21 mmol) of ethyl 1-aminocyclohexanecarboxylate hydrochloride and 3.15 g (21 mmol) of morpholine carbonyl chloride, whereby 1.8 g of the captioned 1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxylic acid was obtained in a yield of 33%.

Workup

  1. customThe same reaction procedure

Sources & evidence

ORD record
ord-1d2032a1737042ca882b5c0444386f18
Source dataset
uspto-grants-2000_09
Patent number
US06117870

Reaction notes

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