Hydrochloric Acid → HCID 178459884, compound

HRID 1953501Notes

Reaction equation

HRID 1953501 reaction equation
[CH2:1]([O:4][C:5](=[O:33])[NH:6][C@@H:7]([C:15]([N:17]1[CH2:21][CH2:20][CH2:19][C@H:18]1[C:22](=[O:32])[NH:23][CH2:24][C@H:25]1[CH2:30][CH2:29][C@H:28]([NH2:31])[CH2:27][CH2:26]1)=[O:16])[C:8]([S:11][CH:12]([CH3:14])[CH3:13])([CH3:10])[CH3:9])[CH2:2][CH3:3].[ClH:34]>C(O)C>[ClH:34].[CH2:1]([O:4][C:5](=[O:33])[NH:6][C@@H:7]([C:15]([N:17]1[CH2:21][CH2:20][CH2:19][C@H:18]1[C:22](=[O:32])[NH:23][CH2:24][C@H:25]1[CH2:26][CH2:27][C@H:28]([NH2:31])[CH2:29][CH2:30]1)=[O:16])[C:8]([S:11][CH:12]([CH3:13])[CH3:14])([CH3:9])[CH3:10])[CH2:2][CH3:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178459883HCID 178459883, compound

Product 1

HCID 178459884HCID 178459884, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

0.49 g of [(S)-1-[(S)-2-[(trans-4-aminocyclohexylmethyl)carbamoyl]pyrrolidine-1-carbonyl]2-isopropylthio-2-methylpropyl]carbamic acid propyl ester obtained in Example 1was dissolved in 5 ml of ethanol, and 1.0 ml of 1N hydrochloric acid was added thereto, followed by stirring at room temperature for 30 minutes. The solvent was distilled off under reduced pressure, and then, 5 ml of toluene was added thereto and then distilled under reduced pressure. The residue was dried under a reduced pressure of about 10 mmHg at room temperature to obtain 0.54 g of a white amorphous substance.

Workup

  1. distillationThe solvent was distilled off under reduced pressure
  2. addition5 ml of toluene was added
  3. distillationdistilled under reduced pressure
  4. customThe residue was dried under a reduced pressure of about 10 mmHg at room temperature
  5. customto obtain 0.54 g of a white amorphous substance

Sources & evidence

ORD record
ord-cd40c98d4f164f46bceef2e60aa2cfd8
Source dataset
uspto-grants-2000_09
Patent number
US06117897

Reaction notes

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