Tryptamine → 1-Indan-5-yl-2,3,4,9-tetrahydro-1H-beta-carboline

HRID 1953511ノート

反応式

HRID 1953511 の反応式
[NH2:1][CH2:2][CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6][CH:5]=1.[CH2:13]1[C:21]2[C:16](=[CH:17][C:18]([CH:22]=O)=[CH:19][CH:20]=2)[CH2:15][CH2:14]1.C(O)(C(F)(F)F)=O>>[CH2:13]1[C:21]2[C:16](=[CH:17][C:18]([CH:22]3[C:5]4[NH:6][C:7]5[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=5)[C:4]=4[CH2:3][CH2:2][NH:1]3)=[CH:19][CH:20]=2)[CH2:15][CH2:14]1

参加物

4

反応物 3

HCID 1150TryptamineHCID 6422Trifluoroacetic acidHCID 1216245-Indanecarboxaldehyde

生成物 1

HCID 108807391-Indan-5-yl-2,3,4,9-tetrahydro-1H-beta-carboline収率 15.6%

実験手順

This product was prepared using the same procedure as for Intermediate 1 with tryptamine (1.28 g, 8.0 mmol), indan-5-carboxaldehyde (1.3 g, 1.1 equiv.) and TFA (1.2 mL, 2 equiv.) to give the title compound (0.36 g, 14%).

後処理

  1. customThis product was prepared

出典と根拠

ORDレコード
ord-cc9c74bb58d5426f8ba6e0b241d81b57
出典データセット
uspto-grants-2000_09
特許番号
US06117881

反応ノート

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