HCID 23298448, compound → HCID 23298401, compound

HRID 1953546Notes

Reaction equation

HRID 1953546 reaction equation
[ClH:1].[N+:2]([C:5]1[CH:13]=[C:12]2[C:8]([CH2:9][CH2:10][CH:11]2[NH:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[CH:7][CH:6]=1)([O-])=O>CO.[Pd]>[ClH:1].[NH2:2][C:5]1[CH:13]=[C:12]2[C:8]([CH2:9][CH2:10][CH:11]2[NH:14][CH2:15][C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)=[CH:7][CH:6]=1

Participants

4

Reactant 1

HCID 23298448HCID 23298448, compound

Product 1

HCID 23298401HCID 23298401, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To 6-nitro-1-(phenylmethyl)aminoindane hydrochloride (1.34 g, 4.40 mmol) in MeOH (100 ml) was added a catalytic amount of 10% Pd/C. The mixture was hydrogenated at 50 psi for 1 hr, filtered through celite, and concentrated to give 6-amino-1-(phenylmethyl)aminoindane hydrochloride which was homogeneous by TLC and used immediately in the next step.

Workup

  1. filtrationfiltered through celite
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-09312a3dd6634c059253d40ef9e27857
Source dataset
uspto-grants-2000_09
Patent number
US06117898

Reaction notes

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