反应详情

6-Bromomethyl-1-oxo-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (1.1 g, 2.96 mmol) obtained in Step 5 was dissolved in N,N-dimethyl formamide. Pyridine (264 μl, 3.26 mmol) and morpholine (284 μl, 3.26 mmol) were added thereto, followed by stirring for 2 hrs. Upon the completion of the reaction, the resulting mixture washed successively with saturated ammonium chloride and saline and extracted with ethyl acetate. The organic layer was separated, dried over anhydrous MgSO4 and concentrated under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 180 mg of the titled compound (yield: 16.1%) in red oil state.

1. customUpon the completion of the reaction
2. washthe resulting mixture washed successively with saturated ammonium chloride and saline
3. extractionextracted with ethyl acetate
4. customThe organic layer was separated
5. dry with materialdried over anhydrous MgSO4
6. concentrationconcentrated under a reduced pressure
7. customThe resulting residue was purified by flash chromatography