反应详情

温度

100 °C

A mixture of 2-amino-6-methoxy-1-tetralone hydrochloride (2 g, 8.79 mmol) and 48% hydrobromic acid (60 mL) was stirred at 100° C. for 2 hours and then increased to 130° C. for additional 100 minutes. The resulting solution was concentrated. The crude product was subjected to re-evaporation with dry toluene and hexane. Upon adding a small amount of ethanol and hexane, a white salt precipitated which was removed. Upon concentrating the filtrate, a purple solid (1.43 g, 63%) resulted.

1. temperatureincreased to 130° C. for additional 100 minutes
2. concentrationThe resulting solution was concentrated
3. customThe crude product was subjected to re-evaporation with dry toluene and hexane
4. additionUpon adding a small amount of ethanol and hexane
5. customa white salt precipitated which
6. customwas removed
7. concentrationUpon concentrating the filtrate