HCID 54189558, compound → HCID 23297809, compound

HRID 1953758Notes

Reaction equation

HRID 1953758 reaction equation
[C:1]([O:5][C:6]([N:8]([CH2:14][C:15]1[CH:27]=[CH:26][C:18]([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])=[CH:17][C:16]=1[N+:28]([O-])=O)[CH2:9][CH2:10][CH:11]([CH3:13])[CH3:12])=[O:7])([CH3:4])([CH3:3])[CH3:2]>C(O)C.[Pd]>[NH2:28][C:16]1[CH:17]=[C:18]([CH:26]=[CH:27][C:15]=1[CH2:14][N:8]([C:6]([O:5][C:1]([CH3:2])([CH3:3])[CH3:4])=[O:7])[CH2:9][CH2:10][CH:11]([CH3:13])[CH3:12])[C:19]([O:21][C:22]([CH3:25])([CH3:23])[CH3:24])=[O:20]

Participants

4

Reactant 1

HCID 54189558HCID 54189558, compound

Product 1

HCID 23297809HCID 23297809, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of t-butyl 4-[N-(t-butoxycarbonyl)-N-(isopentyl)amino-methyl]-3-nitrobenzoate (2.27 mmol) in ethanol (100 mL) containing 10% palladium on carbon (0.5 g) was hydrogenated (40 psi). After 30 min, the mixture was filtered and concentrated to give t-butyl 3-amino-4-[N-(t-butoxycarbonyl)-N-(isopentyl)-aminomethyl]benzoate.

Workup

  1. filtrationthe mixture was filtered
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-d42657b1eded415db88e860a6bbcb04d
Source dataset
uspto-grants-2000_09
Patent number
US06117866

Reaction notes

Loading…