Sodium Azide → HCID 23297968, compound

HRID 1953772Notes

Reaction equation

HRID 1953772 reaction equation
[N-:1]=[N+:2]=[N-:3].[Na+].Br[CH2:6][C:7]1[CH:16]=[C:15]([F:17])[CH:14]=[C:13]2[C:8]=1[N:9]=[C:10]([O:20][CH3:21])[C:11]([O:18][CH3:19])=[N:12]2>CN(C)C=O>[N:1]([CH2:6][C:7]1[CH:16]=[C:15]([F:17])[CH:14]=[C:13]2[C:8]=1[N:9]=[C:10]([O:20][CH3:21])[C:11]([O:18][CH3:19])=[N:12]2)=[N+:2]=[N-:3]

Participants

4

Reactant 2

HCID 33557Sodium AzideHCID 23298034HCID 23298034, compound

Product 1

HCID 23297968HCID 23297968, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

1.73 g (26.6 mmol) of sodium azide are added at room temperature to 4.0 g (13.3 mmol) of 5-bromomethyl-2,3-dimethoxy-7-fluoroquinoxaline in 50 ml of dimethylformamide and stirred for 5 h. The reaction mixture is poured onto water, extracted with diethyl ether and washed with water and brine. The organic phase is dried using Na2SO4, filtered off on a suction filter and concentrated. The title compound is obtained as white crystals of m.p. 75-78° C.

Workup

  1. additionThe reaction mixture is poured onto water
  2. extractionextracted with diethyl ether
  3. washwashed with water and brine
  4. customThe organic phase is dried
  5. filtrationfiltered off on a suction
  6. filtrationfilter
  7. concentrationconcentrated

Sources & evidence

ORD record
ord-909932d32b8c43aa81555225e3904969
Source dataset
uspto-grants-2000_09
Patent number
US06117873

Reaction notes

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