HCID 23297968, compound → HCID 23298016, compound

HRID 1953773Notes

Reaction equation

HRID 1953773 reaction equation
[N:1]([CH2:4][C:5]1[CH:14]=[C:13]([F:15])[CH:12]=[C:11]2[C:6]=1[N:7]=[C:8]([O:18][CH3:19])[C:9]([O:16][CH3:17])=[N:10]2)=[N+]=[N-]>O1CCCC1.[Ni]>[NH2:1][CH2:4][C:5]1[CH:14]=[C:13]([F:15])[CH:12]=[C:11]2[C:6]=1[N:7]=[C:8]([O:18][CH3:19])[C:9]([O:16][CH3:17])=[N:10]2

Participants

4

Reactant 1

HCID 23297968HCID 23297968, compound

Product 1

HCID 23298016HCID 23298016, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 8028TetrahydrofuranSolvent

Procedure

3.5 g (13.3 mmol) of 5-azidomethyl-2,3-dimethoxy-7-fluoroquinoxaline in 35 ml of tetrahydrofuran are hydrogenated at room temperature for about 19 hours in the presence of 1.75 g of Raney nickel. The reaction mixture is filtered off and concentrated. The title compound is obtained as yellowish crystals.

Workup

  1. filtrationThe reaction mixture is filtered off
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-0112157c543e468e99695a0498baafe4
Source dataset
uspto-grants-2000_09
Patent number
US06117873

Reaction notes

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