HCID 54370181, compound → HCID 10451888, compound

HRID 1953781Notes

Reaction equation

HRID 1953781 reaction equation
[N+:1]([C:4]1[CH:13]=[C:12]2[C:7]([N:8]=[C:9]([O:16]C)[C:10]([O:14]C)=[N:11]2)=[C:6]([CH2:18][N:19]([CH2:28][CH3:29])[C@H:20]([P:22](=[O:27])([O:25]C)[O:23]C)[CH3:21])[CH:5]=1)([O-:3])=[O:2]>Cl>[N+:1]([C:4]1[CH:13]=[C:12]2[C:7]([NH:8][C:9](=[O:16])[C:10](=[O:14])[NH:11]2)=[C:6]([CH2:18][N:19]([CH2:28][CH3:29])[C@H:20]([P:22](=[O:23])([OH:27])[OH:25])[CH3:21])[CH:5]=1)([O-:3])=[O:2]

Participants

3

Reactant 1

HCID 54370181HCID 54370181, compound

Product 1

HCID 10451888HCID 10451888, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

4.24 g (9.9 mmol) of dimethyl (R)-N-(7-nitro-2,3-dimethoxyquinoxalin-5-ylmethyl)-α-ethylaminoethylphosphonate are stirred for 19 hours in 80 ml of 6N hydrochloric acid. The reaction mixture is evaporated and the residue is slurried with water. The title compound is obtained as a solid of m.p.=218° C. (dec.).

Workup

  1. customThe reaction mixture is evaporated

Sources & evidence

ORD record
ord-6d37ef974b8448ee98e381f1fd502791
Source dataset
uspto-grants-2000_09
Patent number
US06117873

Reaction notes

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