反应详情

200 mg (0.757 mmol) of 5-aminomethyl-7-nitro-2,3-dimethoxyquinoxaline, 547 mg (4.5 eq.) of magnesium sulfate and 163 mg (1.3 eq.) of dimethyl 2-oxopropylphosphonate are stirred at room temperature for 20 hours in 8 ml of dichloromethane. 4 ml of methanol, 0.095 ml of acetic acid and 52 mg (1.1 eq.) of sodium cyanoborohydride are then added and stirred for 4 hours. The reaction mixture is then filtered and the filtrate is extracted with water and brine. The organic phases are combined, dried over magnesium sulfate and evaporated. The title compound is obtained as a brown oil.

1. filtrationThe reaction mixture is then filtered
2. extractionthe filtrate is extracted with water and brine
3. dry with materialdried over magnesium sulfate
4. customevaporated