1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride → HCID 23297994, compound

HRID 1953785Notes

Reaction equation

HRID 1953785 reaction equation
Cl.CN(CCCN=C=NCC)C.[NH2:13][CH2:14][C:15]1[CH:24]=[C:23]([N+:25]([O-:27])=[O:26])[CH:22]=[C:21]2[C:16]=1[N:17]=[C:18]([O:30][CH3:31])[C:19]([O:28][CH3:29])=[N:20]2.[CH3:32][O:33][P:34]([CH2:38][CH2:39][CH2:40][C:41](O)=[O:42])([O:36][CH3:37])=[O:35]>C(Cl)Cl>[CH3:29][O:28][C:19]1[C:18]([O:30][CH3:31])=[N:17][C:16]2[C:21](=[CH:22][C:23]([N+:25]([O-:27])=[O:26])=[CH:24][C:15]=2[CH2:14][NH:13][C:41](=[O:42])[CH2:40][CH2:39][CH2:38][P:34]([O:33][CH3:32])([O:36][CH3:37])=[O:35])[N:20]=1

Participants

5

Reactant 3

HCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 2773768Dimethyl(3-carboxypropyl)phosphonateHCID 179152965-Aminomethyl-2,3-dimethoxy-7-nitro-quinoxaline

Product 1

HCID 23297994HCID 23297994, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

163 mg (0.851 mmol) of N-(dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride are added at room temperature to a solution of 150 mg (0.568 mmol) of 5-aminomethyl-2,3-dimethoxy-7-nitroquinoxaline and 165 mg (0.738 mmol) of 4-(dimethylphosphono)butyric acid in 3 ml of methylene chloride and the mixture is stirred for 30 hours. The mixture is then diluted with methylene chloride and washed with 0.2N hydrochloric acid and brine and concentrated on a rotary evaporator, and the residue is dried in a high vacuum. The title compound is obtained as a yellow resin.

Workup

  1. washwashed with 0.2N hydrochloric acid and brine
  2. concentrationconcentrated on a rotary evaporator
  3. customthe residue is dried in a high vacuum

Sources & evidence

ORD record
ord-f7b099016d3d48428756f05e13472684
Source dataset
uspto-grants-2000_09
Patent number
US06117873

Reaction notes

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