反应详情

温度

150 °C

2-Bromo-3-phenyl-6-(3-phenyl-propoxy)-indene-1-one (1.0 g, 2.3 mmol) obtained in Step 2 was dissolved in N,N-dimethyl formamide (10 mL), copper(I) cyamide (617 mg, 6.9 mmol) was added thereto, and the mixture was stirred for 3 hrs at 150° C., followed by cooling. The resulting mixture was washed with saturated ammonium chloride and extracted with ethyl acetate. The organic layer was separated, dried over anhydrous MgSO4 and concentrated under a reduced pressure. The resulting residue was purified by flash chromatography (ethyl acetate:hexane=1:3) to obtain 700 mg of the titled compound (yield: 80%) as a red solid.

1. temperatureby cooling
2. washThe resulting mixture was washed with saturated ammonium chloride
3. extractionextracted with ethyl acetate
4. customThe organic layer was separated
5. dry with materialdried over anhydrous MgSO4
6. concentrationconcentrated under a reduced pressure
7. customThe resulting residue was purified by flash chromatography (ethyl acetate:hexane=1:3)