反应详情

50.4 g (0.6 mol) of sodium bicarbonate were added in small amounts at room temperature to a solution of 19.4 g (0.2 mol) of 3-amino-5-methyl-1H-pyrazole in 200 cm3 of water. 37.8 cm3 (0.4 mol) of acetic anhydride were added dropwise to this solution and then the mixture was heated at reflux for 2 hours. The solution was subsequently brought back to room temperature, a white solid crystallized and was pulled dry on sintered glass and then washed with 100 cm3 of water. After drying under vacuum at 40° C., 16.6 g of the expected product were obtained in the form of pearlescent-white crystals, the melting point of which was between 210° C. and 212° C.

1. temperaturethe mixture was heated
2. temperatureat reflux for 2 hours
3. customwas subsequently brought back to room temperature
4. customa white solid crystallized
5. customwas pulled dry on sintered glass
6. washwashed with 100 cm3 of water
7. customAfter drying under vacuum at 40° C.