Benzoyl chloride → 1-Benzoyl-4-bromopiperidine

HRID 1953805ノート

反応式

HRID 1953805 の反応式
[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br.[Br:11][CH:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1.C(N(CC)CC)C>C1COCC1>[C:1]([N:15]1[CH2:16][CH2:17][CH:12]([Br:11])[CH2:13][CH2:14]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 7412Benzoyl chlorideHCID 8471TriethylamineHCID 27346764-Bromopiperidine Hydrobromide

生成物 1

HCID 156154171-Benzoyl-4-bromopiperidine収率 102.9%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Benzoyl chloride (1.41 g) was added to a solution of 4-bromopiperidine hydrobromide (2.45 g) in THF (30 ml) at 0° C., followed by triethylamine (2.2 g, 2.2 eq). The solution was stirred at room temperature for 1 h, and evaporated and. The residue was dissolved in dichloromethane (100 ml), washed with water, 1M HCl and saturated sodium bicarbonate, dried and evaporated to give the title compound as colourless oil (2.76 g, 100%).

後処理

  1. customevaporated
  2. dissolutionThe residue was dissolved in dichloromethane (100 ml)
  3. washwashed with water, 1M HCl and saturated sodium bicarbonate
  4. customdried
  5. customevaporated

出典と根拠

ORDレコード
ord-5a3be90131314de5928df8f2e7b55486
出典データセット
uspto-grants-2000_09
特許番号
US06118001

反応ノート

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