Trifluoroacetic acid → HCID 54066020, compound

Participants

Reaction Steps

Step, iii: (S)-2-[(4-tert-Butyl-benzyl)-methyl-amino]-4-methyl-pentanoic acid tert-butyl ester (0.5 g, 1.4 mmol) was dissolved in CH2Cl2 (10 mL) and treated with TFA (1mL). After 1 hour, 0.5 mL TFA was added, followed by another 1 mL TFA at 2.5 hours. The reaction was stirred overnight, then concentrated to give (S)-2-[(4-tert-butyl-benzyl)-methyl-amino]-4-methyl-pentanoic acid (IIc).

Provenance & Evidence