Trifluoroacetic acid → HCID 54066020, compound

HRID 1953907Notes

Reaction equation

HRID 1953907 reaction equation
C([O:5][C:6](=[O:25])[C@@H:7]([N:12]([CH2:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]([CH3:24])([CH3:23])[CH3:22])=[CH:17][CH:16]=1)[CH3:13])[CH2:8][CH:9]([CH3:11])[CH3:10])(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[C:21]([C:18]1[CH:19]=[CH:20][C:15]([CH2:14][N:12]([CH3:13])[C@@H:7]([CH2:8][CH:9]([CH3:10])[CH3:11])[C:6]([OH:25])=[O:5])=[CH:16][CH:17]=1)([CH3:22])([CH3:24])[CH3:23]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acid3×HCID 54120602HCID 54120602, compound

Product 1

HCID 54066020HCID 54066020, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Step, iii: (S)-2-[(4-tert-Butyl-benzyl)-methyl-amino]-4-methyl-pentanoic acid tert-butyl ester (0.5 g, 1.4 mmol) was dissolved in CH2Cl2 (10 mL) and treated with TFA (1mL). After 1 hour, 0.5 mL TFA was added, followed by another 1 mL TFA at 2.5 hours. The reaction was stirred overnight, then concentrated to give (S)-2-[(4-tert-butyl-benzyl)-methyl-amino]-4-methyl-pentanoic acid (IIc).

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-1f084cbadda24143811a68244344e5a1
Source dataset
uspto-grants-2000_09
Patent number
US06117841

Reaction notes

Loading…