Hydrazinecarboxaldehyde → HCID 53660506, compound

HRID 1953981Notes

Reaction equation

HRID 1953981 reaction equation
[CH:1]([NH:3][NH2:4])=[O:2].[Cl:5][C:6]1[C:11]([O:12][C:13]2[C:18]([C:19]([F:22])([F:21])[F:20])=[CH:17][CH:16]=[CH:15][N:14]=2)=[CH:10][C:9]([N:23]=[C:24]=[S:25])=[C:8]([F:26])[CH:7]=1>O1CCCC1>[Cl:5][C:6]1[C:11]([O:12][C:13]2[C:18]([C:19]([F:22])([F:21])[F:20])=[CH:17][CH:16]=[CH:15][N:14]=2)=[CH:10][C:9]([NH:23][C:24]([N:3]([CH:1]=[O:2])[NH2:4])=[S:25])=[C:8]([F:26])[CH:7]=1

Participants

4

Reactant 2

HCID 12229HydrazinecarboxaldehydeHCID 18402951HCID 18402951, compound

Product 1

HCID 53660506HCID 53660506, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Formic hydrazide (0.6 g) was added to a mixture of 4-chloro-2-fluoro-5-(3-trifluoromethyl-2-pyridyloxy)phenyl isothiocyanate (3.4 g) in tetrahydrofuran (20 ml) and the mixture was stirred for 3 hours at room temperature. The solvent was removed under reduced pressure and the residue processed. The resulting oil was dissolved in ethanol (30 ml), and hexane added to induce crystallization. The crystals were filtered and dried to give the product, (3.5 g, 69%).

Workup

  1. customThe solvent was removed under reduced pressure
  2. dissolutionThe resulting oil was dissolved in ethanol (30 ml)
  3. additionhexane added
  4. customcrystallization
  5. filtrationThe crystals were filtered
  6. customdried
  7. customto give the product, (3.5 g, 69%)

Sources & evidence

ORD record
ord-9d8f1c7a65f34a95848616b1fd5bbf78
Source dataset
uspto-grants-2000_09
Patent number
US06121201

Reaction notes

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