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0 °C

1-Oxo-3-phenyl-6-(3-phenylpropoxy)-1H-indene-2-carbonitrile (350 mg, 0.878 mmol) obtained in Step 1 was dissolved in THF, and phenylmagnesium chloride (0.483 mL, 0.966 mmol) was added thereto, followed by stirring for 3 hrs at 0° C. Upon the completion of the reaction, the mixture washed with saturated saline and extracted with ethyl acetate. The organic layer was separated, dried over anhydrous MgSO4 and concentrated under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 378 mg of the titled compound (yield: 90%).

1. customUpon the completion of the reaction
2. washthe mixture washed with saturated saline
3. extractionextracted with ethyl acetate
4. customThe organic layer was separated
5. dry with materialdried over anhydrous MgSO4
6. concentrationconcentrated under a reduced pressure
7. customThe resulting residue was purified by flash chromatography