Methyl chloroformate → 151830-35-2

HRID 1954003Notes

Reaction equation

HRID 1954003 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][OH:9].C(=O)(O)[O-].[Na+].Cl[C:16]([O:18][CH3:19])=[O:17]>C(Cl)Cl>[OH:9][N:8]([C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[CH3:1])[C:16](=[O:17])[O:18][CH3:19]

Participants

5

Reactant 3

HCID 6586Methyl chloroformateHCID 11908N-Hydroxy-2-toluidineHCID 516892Sodium Bicarbonate

Product 1

HCID 21191822151830-35-2

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a 250 ml 3-neck RBF, stirring under nitrogen atmosphere, was charged 16.1 g (1.0 eq., 0.13 moles) N-2-methylphenylhydroxyamine in 40 ml methylene chloride and 16.8 g (1.5 eq., 0.20 moles) sodium bicarbonate neat. With a pipet added 13.1 g (1.05 eq, 0.37 moles) methyl chloroformate neat to the mixture at -5° C. to +5° C. The reaction mixture was stirred at 0° C. for 30 min. following the addition and the reaction was monitored by GC.

Workup

  1. stirringThe reaction mixture was stirred at 0° C. for 30 min.
  2. additionthe addition

Sources & evidence

ORD record
ord-ac7f223146ad42fe9e13a622d85cda45
Source dataset
uspto-grants-2000_09
Patent number
US06121251

Reaction notes

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