反应详情

Compound 18 (7.33 g, 8.99 mmol) was prepared from 16 (5.30 g, 9.99 mmol), 15 (4.13 g, 10.0 mmol), and NaHCO3 (2.52 g, 30.0 mmol) in 90% yield by the same method used for the preparation of 17. For 18: mp 138-140° C.; 1H NMR (DMSO-d6) d 1.50 (s, 9H, 3×CH3), 3.72, 3.83 (AB, Jgem =19 Hz, 2H, CH2S), 4.60 (s, 2H, OCH2CO), 4.99, 5.29 (AB, Jgem =15 Hz, 2H, CH2O), 5.18 (d, J=5.0 Hz, 1H, HC(6)), 5.79 (dd, J=5.0 and 9.5 Hz, 1H, HC(7)), 6.20 (br, 3H, 3×OH), 6.90-7.50 (m, 14H, 4×ArH), 8.30 (d, J=9.5 Hz, 1H, NH); IR (nujol): 3290-3370 (OH, NH), 1792 (β-lactam), 1750 (ester), 1730 (ester), 1688 (amide), 1620 (C=O) cm-1. Anal. (C41H35N2O12SCl) C, H, N, S, Cl.