tert-Butyl methyl ether → HCID 178435105, compound

HRID 1954206Notes

Reaction equation

HRID 1954206 reaction equation
[CH3:1][C:2]1[N:3]=[CH:4][S:5][C:6]=1[CH3:7].[Br:8]CC([C:12]1[S:13][CH:14]=[CH:15][CH:16]=1)=O.C[O:18][C:19](C)(C)[CH3:20]>C(O)C>[Br-:8].[SH:13]1([C:19](=[O:18])[CH2:20][N+:3]2[C:2]([CH3:1])=[C:6]([CH3:7])[S:5][CH:4]=2)[CH:12]=[CH:16][CH:15]=[CH:14]1

Participants

5

Reactant 3

HCID 15413tert-Butyl methyl etherHCID 625104,5-DimethylthiazoleHCID 27763722-Bromo-1-(thiophen-2-yl)ethan-1-one

Product 1

HCID 178435105HCID 178435105, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 4,5-dimethylthiazole (2.2 g, 19.4 mmol) and 2-bromoacetylthiophene (4 g, 19.4 mmol) in ethyl alcohol (20 mL) was refluxed for 3 hours. It was cooled to room temperature and t-butyl methyl ether (10 mL) was added. The reaction mixture was left at room temperature overnight with stirring. The white product separated and was filtered and dried. It was crystallized from ethyl alcohol (4.42 g, 73%), m.p. 203-205° C.

Workup

  1. customThe white product separated
  2. filtrationwas filtered
  3. customdried
  4. customIt was crystallized from ethyl alcohol (4.42 g, 73%), m.p. 203-205° C.

Sources & evidence

ORD record
ord-3c69eb6bb387471a8e6850e0c125cffb
Source dataset
uspto-grants-2000_09
Patent number
US06121300

Reaction notes

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