HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine, 4-(chloroacetyl)- → Diethyl 2-amino-6-[(2-oxo-2-morpholin-4-yl-ethoxycarbamoyl)-methyl]-azulene-1,3-dicarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine, 4-(chloroacetyl)- | HCID 74040 | — |
| Reactant | Diethyl 2-amino-6-[(hydroxycarbamoyl)-methyl]-azulene-1,3-dicarboxylate sodium | HCID 86755843 | — |
| Product | Diethyl 2-amino-6-[(2-oxo-2-morpholin-4-yl-ethoxycarbamoyl)-methyl]-azulene-1,3-dicarboxylate | HCID 15411821 | 33% |
Reaction Steps
In an analogous manner to that described in Example 1, from diethyl 2-amino-6-[(hydroxycarbamoyl)-methyl]-azulene-1,3-dicarboxylate sodium and N-chloroacetyl-morpholine the title compound of m.p. 196-198° C. is obtained in 33% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06121322 |
| Source dataset | uspto-grants-2000_09 |
| ORD ID | ord-f5f5584289d4448aaf671a4280873fb2 |
| Source note | uspto-grants-2000_09 |