4'-(Trifluoromethyl)(1,1'-biphenyl)-2-carboxylic acid → HCID 23296221, compound

HRID 1954411Notes

Reaction equation

HRID 1954411 reaction equation
CN1C=CC=C1[CH2:7][CH2:8][N:9]1[CH2:18][CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[C:14]([NH:19][C:20]([C:22]3[C:23]([C:28]4[CH:33]=[CH:32][C:31]([C:34]([F:37])([F:36])[F:35])=[CH:30][CH:29]=4)=[CH:24][CH:25]=[CH:26][CH:27]=3)=[O:21])[CH:15]=2)[CH2:10]1.FC(F)(F)C1C=CC(C2C(C(O)=O)=CC=CC=2)=CC=1.C1(C(C2C=CC=CC=2)CN2CCC3C(=CC=[C:70]([NH:75][C:76](C4C(C5C=CC(C(F)(F)F)=CC=5)=CC=CC=4)=[O:77])C=3)C2)C=CC=CC=1.C1(CCC2C3C(=CC(NC(C4C(C5C=CC(C(F)(F)F)=CC=5)=CC=CC=4)=O)=CC=3)CC[NH:109]2)C=CC=CC=1.N1CCC(N2CCC3C(=CC=C(NC(C4C(C5C=CC(C(F)(F)F)=CC=5)=CC=CC=4)=O)C=3)C2)CC1>>[CH3:70][NH:75][C:76](=[O:77])[NH:109][CH2:7][CH2:8][N:9]1[CH2:10][CH2:11][C:12]2[C:17](=[CH:16][CH:15]=[C:14]([NH:19][C:20]([C:22]3[C:23]([C:28]4[CH:33]=[CH:32][C:31]([C:34]([F:37])([F:36])[F:35])=[CH:30][CH:29]=4)=[CH:24][CH:25]=[CH:26][CH:27]=3)=[O:21])[CH:13]=2)[CH2:18]1

Participants

6

Reactant 5

HCID 552514'-(Trifluoromethyl)(1,1'-biphenyl)-2-carboxylic acid2×HCID 10231808HCID 10231808, compoundHCID 23296180HCID 23296180, compoundHCID 23296217HCID 23296217, compoundHCID 23296225HCID 23296225, compound

Product 1

HCID 23296221HCID 23296221, compound

Procedure

##STR5## 4'-Trifluoromethylbiphenyl-2-carboxylic acid-{2- [2-(1-methyl-1H-pyrrol-2-yl)ethyl]-1,2,3,4-tetrahydroisoquinolin-6-yl}-amide; ##STR6## 4'-Trifluoromethylbiphenyl-2-carboxylic acid-{2-[2-(2H-[1,2,4]triazol-3-yl-ethyl]-1,2,3,4-tetrahydroisoquinolin-6-yl}-amide; ##STR7## 4'-Trifluoromethylbiphenyl-2-carboxylic acid-[2-(2,2-diphenylethyl)-1,2,3,4-tetrahydroisoquinolin-6-yl]-amide; ##STR8## 4'-Trifluoromethylbiphenyl-2-carboxylic acid-[2-(2-pyridin-2-yl-ethyl-1,2,3,4-tetrahydroisoquinolin-6-yl]-amide; ##STR9## 4'-Trifluoromethylbiphenyl-2-carboxylic acid-(2-phenylethyl-1,2,3,4-tetrahydroisoquinolin-6-yl)-amide; ##STR10## 4'-Trifluoromethylbiphenyl-2-carboxylic acid-(2-piperidin-4-yl-1,2,3,4-tetrahydroisoquinolin-6-yl)-amide; and ##STR11## 4'-Trifluoromethylbiphenyl-2-carboxylic acid-[2-(1-trifluoromethylacetyl-piperidin-4-yl)-1,2,3,4-tetrahydroisoquinolin-6-yl]-amide.

Sources & evidence

ORD record
ord-619ef28bff444baa909e2e672b127ae8
Source dataset
uspto-grants-2000_09
Patent number
US06121283

Reaction notes

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