4'-(Trifluoromethyl)(1,1'-biphenyl)-2-carboxylic acid → HCID 23296221, compound

https://huagongshe.com/reaction/1954411

Participants

Role	Name	HCID	Charge
Reactant	4'-(Trifluoromethyl)(1,1'-biphenyl)-2-carboxylic acid	HCID 55251	—
Reactant	HCID 10231808	HCID 10231808	—
Reactant	HCID 23296180	HCID 23296180	—
Reactant	HCID 23296217	HCID 23296217	—
Reactant	HCID 23296225	HCID 23296225	—
Product	HCID 23296221	HCID 23296221	—

Reaction Steps

##STR5## 4'-Trifluoromethylbiphenyl-2-carboxylic acid-{2- [2-(1-methyl-1H-pyrrol-2-yl)ethyl]-1,2,3,4-tetrahydroisoquinolin-6-yl}-amide; ##STR6## 4'-Trifluoromethylbiphenyl-2-carboxylic acid-{2-[2-(2H-[1,2,4]triazol-3-yl-ethyl]-1,2,3,4-tetrahydroisoquinolin-6-yl}-amide; ##STR7## 4'-Trifluoromethylbiphenyl-2-carboxylic acid-[2-(2,2-diphenylethyl)-1,2,3,4-tetrahydroisoquinolin-6-yl]-amide; ##STR8## 4'-Trifluoromethylbiphenyl-2-carboxylic acid-[2-(2-pyridin-2-yl-ethyl-1,2,3,4-tetrahydroisoquinolin-6-yl]-amide; ##STR9## 4'-Trifluoromethylbiphenyl-2-carboxylic acid-(2-phenylethyl-1,2,3,4-tetrahydroisoquinolin-6-yl)-amide; ##STR10## 4'-Trifluoromethylbiphenyl-2-carboxylic acid-(2-piperidin-4-yl-1,2,3,4-tetrahydroisoquinolin-6-yl)-amide; and ##STR11## 4'-Trifluoromethylbiphenyl-2-carboxylic acid-[2-(1-trifluoromethylacetyl-piperidin-4-yl)-1,2,3,4-tetrahydroisoquinolin-6-yl]-amide.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06121283
Source dataset	uspto-grants-2000_09
ORD ID	ord-619ef28bff444baa909e2e672b127ae8
Source note	uspto-grants-2000_09