Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4'-(Trifluoromethyl)(1,1'-biphenyl)-2-carboxylic acid → 6-[(4'-Trifluoromethyl-biphenyl-2-carbonyl)-amino]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4'-(Trifluoromethyl)(1,1'-biphenyl)-2-carboxylic acid | HCID 55251 | — |
| 반응물 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 반응물 | 6-Amino-2-N-Boc-1,2,3,4-tetrahydro-isoquinoline | HCID 2756371 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 6-[(4'-Trifluoromethyl-biphenyl-2-carbonyl)-amino]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester | HCID 15548823 | — |
반응 단계
A 7.6 g (29 mmol) sample of 4'-trifluoromethyl-biphenyl-2-carboxylic acid, 7.1 g (29 mmol) of 6-amino-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester, 100 mg of DMAP and 6.1 g (32 mmol) of EDCl were reacted in 130 mL of methylene chloride for 12 hrs. The reaction mixture was extracted with 2×150 mL 1N HCl, 2×150 mL 1N NaOH, 150 mL water, brine and then concentrated to yield 14 g of a beige foam.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06121283 |
| 출처 데이터셋 | uspto-grants-2000_09 |
| ORD ID | ord-9b7bb983b6444c9dad4cde0bf59f1663 |
| 출처 메모 | uspto-grants-2000_09 |