反应详情

A 7.6 g (29 mmol) sample of 4'-trifluoromethyl-biphenyl-2-carboxylic acid, 7.1 g (29 mmol) of 6-amino-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester, 100 mg of DMAP and 6.1 g (32 mmol) of EDCl were reacted in 130 mL of methylene chloride for 12 hrs. The reaction mixture was extracted with 2×150 mL 1N HCl, 2×150 mL 1N NaOH, 150 mL water, brine and then concentrated to yield 14 g of a beige foam.

1. extractionThe reaction mixture was extracted with 2×150 mL 1N HCl, 2×150 mL 1N NaOH, 150 mL water, brine
2. concentrationconcentrated