Hydrochloric Acid → N-(3-{2-[amino(dicyclopropyl)methyl]-1,3-thiazol-5-yl}-5-methylphenyl)-4-(trifluoromethyl)-pyrimidin-2-amine

HRID 195443Notes

Reaction equation

HRID 195443 reaction equation
[CH3:39][OH:40].[CH:1]1([C:4]([NH:5][S:6]([C:7]([CH3:8])([CH3:9])[CH3:10])=[O:11])([c:12]2[s:13][c:14](-[c:17]3[cH:18][c:19]([CH3:34])[cH:20][c:21]([NH:23][c:24]4[n:25][cH:26][cH:27][c:28]([C:30]([F:31])([F:32])[F:33])[n:29]4)[cH:22]3)[cH:15][n:16]2)[CH:35]2[CH2:36][CH2:37]2)[CH2:2][CH2:3]1.[ClH:38]>>[CH:1]1([C:4]([NH2:5])([c:12]2[s:13][c:14](-[c:17]3[cH:18][c:19]([CH3:34])[cH:20][c:21]([NH:23][c:24]4[n:25][cH:26][cH:27][c:28]([C:30]([F:31])([F:32])[F:33])[n:29]4)[cH:22]3)[cH:15][n:16]2)[CH:35]2[CH2:36][CH2:37]2)[CH2:2][CH2:3]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 67430001N-[dicyclopropyl-[5-[3-methyl-5-[[4-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-1,3-thiazol-2-yl]methyl]-2-methylpropane-2-sulfinamide

Product 1

HCID 58456217N-(3-{2-[amino(dicyclopropyl)methyl]-1,3-thiazol-5-yl}-5-methylphenyl)-4-(trifluoromethyl)-pyrimidin-2-amine

Sources & evidence

ORD record
ord-d5ab01ef001e48f5b14bcc2f318dc4ee
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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