反应详情

6-Methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (1.5 g, 5.10 mmol) prepared in Preparation Example 1 was dissolved in dichloromethane (80 mL), and N-bromosuccinimide (1.09 g, 6.12 mmol) and 2,2′-azobisisobutyronitrile (0.08 mg, 0.51 mmol) were added thereto. The mixture was stirred for 2 hrs at RT under the irradiation of a 375 W tungsten lamp. Upon the completion of the reaction, the mixture washed with saturated saline and extracted with dichloromethane. The organic layer was separated, dried over anhydrous MgSO4 and concentrated under a reduced pressure. The resulting residue was purified by flash chromatography (ethyl acetate/n-hexane=1/20→1/9) to obtain 1.4 g of the titled compound (yield: 74%) as a yellow solid.

1. customUpon the completion of the reaction
2. washthe mixture washed with saturated saline
3. extractionextracted with dichloromethane
4. customThe organic layer was separated
5. dry with materialdried over anhydrous MgSO4
6. concentrationconcentrated under a reduced pressure
7. customThe resulting residue was purified by flash chromatography (ethyl acetate/n-hexane=1/20→1/9)